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Nanobiotechnology and Cell Molecular

Imaging Laboratory


Department of Biomedical Engineering


Fichter KM, Flajolet M, Greengard P, Vu TQ. Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc Natl Acad Sci USA, 107(43):18658-63, 2010.


Long BR and Vu TQ. Spatial structure and diffusive dynamics from single particle trajectories using spline analysis. Biophysical Journal, 98(8):1712-21, 2010. (PDF)


Nanotechnology Research: Applications in Nutritional Sciences. Srinivas PR, Philbert M, Vu TQ, Huang, Q, Kokini JL, Saos E, Chen H, Peterson CM, Friedl KE, McDade-Ngutter C, Hubbard V, Starke-Reed P, Miller N, Betz JM, Dwyer J, Milner J, Ross SA. The Journal of Nutrition. 140(1):119-24, 2010. (PDF)




Scholl B, Liu HY, Long BR, McCarty OJ, O'Hare T, Druker BJ, Vu TQ. Single Particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis. ACS Nano, 3(6): 1318-28, 2009. (PDF)

Altick AL, Baryshnikova LM, Vu, TQ, von Bartheld CS. Quantitative
Analysis of Multivesicular Bodies (MVBs) in the Hypoglossal Nerve: Evidence that Neurotrophic Factors do not use MVBs for Retrograde Axonal Transport. J Comp Neurology, 514(6):641-57, 2009. (PDF)

Fichter KM, Ardeshiri A, and Vu TQ. Tracking Single Biomolecules in Live Cells Using Quantum Dots. Series Eds: Yarmush, ML and Langer RS.
Methods in Bioengineering Series. Artech House.

Vu TQ and Liu HY. Quantum Dot Hybrid Gel Blotting: A Technique for Identification of Quantum Dot-Protein/Protein-Protein Interactions. In: Nanoscale Molecular-Interaction Technologies in Manipulation of Biomolecules. Eds. Lee, JW and Foote, RS.
Methods in Molecular Biology, 544:381-91, 2009.


Sundara Rajan S, Liu HY, and Vu TQ. Ligand-Bound Quantum Dots for Studying the Molecular Scale Dynamics of Receptor Endocytic Trafficking in Live Cells. ACS Nano, 2(6), 1153-1166, 2008. (PDF)

Pattani VP, Li C, Desai TA, and Vu TQ. Microcontact Printing of Quantum Dot Bioconjugate Arrays For Localized Capture and Detection of Biomolecules,
Biomedical Microdevices, 10(3):367-73, 2008. (PDF)

Zhang F, Ulrich B, Reddy RK, Venkatraman VL, Prasad S, Vu TQ, and Hsu ST. Fabrication of Submicron IrO2 Nanowire Array Biosensor Platform by Conventional Complementary Metal-Oxide-Semiconductor Process. Japanese Journal of Applied Physics, 47(2):1147-1151, 2008.

Vartanian KB, Kirkpatrick SJ, McCarty OJ, Vu TQ, Hanson SR, Hinds MT. Distinct Extracellular Matrix Microenvironments of Progenitor and Carotid Endothelial Cells. J Biomed Mater Res A, (epub ahead of print), 2008.

Related Patent:
Nanoparticle Platforms for Sorting, Capture, and Placement of Cells


Liu HY and Vu TQ. Identification of Quantum Dot Bioconjugates and Cellular Protein Co-localization by Hybrid Gel BLotting. Nano Letters, 7(4):1044-9, 2007. (PDF)

Related Patent:
A Method for Separation and Identification of Proteins Using Unconventional Gel Electrophoresis and Nanoparticle Quantum Dot Tags

Vu TQ, Sundara Rajan S, and Liu HY. Ligand Bound Quantum Dots for Intracellular Imaging of NeuralReceptors.
Proceedings of SPIE, Colloidal Quantum Dots for Biomedical Appliations, Vol. 6448, 2007.


Sundara Rajan S and Vu, TQ. Quantum Dots Monitor TrkA Receptor Dynamics in the Interior of Neural PC12 Cells. Nano Letters 2006 Sep;6(9):2049-59. (PDF)

Vu TQ, Rajan SS. Quantum Dot Imaging in for Imaging and Diagnostics. In:
At the Building Block Level: Nanotechnology for Biology and Medicine, Editor: Silva, GA. Springer Scientific, (submitted)


Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, and Desai TA. Peptide-Conjugated Quantum Dots Activate Neuronal Receptors and Initiate Downstream Signaling of Neurite Growth, Nano Letters 5(4): 603-607, 2005. (PDF)

Nehilla, BJ; Vu, TQ; Desai, TA. Stoichiometry-Dependent Formation of Quantum Dot-Antibody Bioconjugates: A Complementary Atomic Force Microscopy and Agarose Gel Electrophoresis Study.
J. Phys. Chem. B. 109(44); 20724-20730, 2005. (PDF)

Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, and Desai TA. Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. Proceedings of the Special Topic Conference on Microtechnologies,
IEEE in Engineering in Biology and Medicine, Hawaii, pg.152-3, 2005.

Vu TQ, Qian H, Standaert RF, Chowdhurry S, Pepperberg DR. Activation of Neural Receptor Channels Using Neurotransmitter Conjugates Designed for Surface Attachment.
Biomaterials, 25(14):1605-2195, 2005. (PDF)



Beth A. Manhat, Anna L. Brown, Labe A. Black, J. B. Alexander Ross, Katye Fichter, Tania Vu, Erik Richman, and Andrea M. Goforth. One-Step Melt Synthesis of Water-Soluble, Photoluminescent, Surface-Oxidized Silicon Nanoparticles for Cellular Imaging Applications. Chem Mat. 2011. (PDF)




Chiu SK, Manhat BA, DeBenedetti WJ, Brown AL, Fichter KM, Vu TQ, Eastman M, Jiao J, Goforth AM.  Aqeous red emitting silicon nanoparticles for cellular imaging: Consequences of protecting against surface passivation by hydroxide and water for stable, red emission Journal of Material Research  Vol 28 (02): 216-230)

Fichter  KM., and Vu TQ  Tracing the endocytic pathways and trafficking kinetics of cell signaling receptors using single QD nanoparticles. Methods in Molecular Biology: Cellular and Subcellular Nanotechnology. (991:237-47)






Vermehren-Schmaedick A, Krueger W, Jacob T, Ramunno-Johnson D, Balkowiec A, Lidke KA, Vu TQ.  Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. Plos One 2014 Apr 14;9(4)



Vu TQ, Lam WY, Hatch E, Lidke D.  Quantum dot for quantitative imaging: from single molecules to tissueCell and Tissue Research        2015 Apr; 360(1):71-86. Review.


Jacob T, Agarwal A, Ramunno-Johnson D, O'Hare T, Gönen M, Tyner JW, Druker BJ, Vu TQ.  Ultrasensitive proteomic quantitation of Cellular signaling by digitized nanoparticle-protein counting. Scientific Reports. 2016 Jun 20;6:28163   (PDF)

PMID: 27320899.  


Jacob, T., Gray, JW., Troxell, M. & Vu, TQ. Multiplexed imaging reveals heterogeneity of PI3K/MAPK network signaling in breast lesions of known PIK3CA genotype. Breast Cancer Res Treat, DOI: 10.1007/s10549-016-3962-1, 1-9 (2016). PMID: 27581127


Roberts E, Jacob T, Garsha, K, Ramunno-Johnson D, Ventura, F., Korkola J, Ashworth-Sharpe J, Johnson D, Corless CL, Troxell ML, Barnes M, Gray J, Shanmugam K, Vu TQ. Mapping cancer signaling networks by an integrated multiplexed tissue imaging platform. Technology. 2016 September 21; 04(03):174-193  (PDF)


Pre - 2005

Nehilla BJ, Popat KC, Vu TQ, Chowdhurry S, Standaert RF, Pepperberg DR, and Desai TA. A Neurotransmitter Analog Tethered to a Silicon Platform for Neuro-bioMEMS Applications, Biotechnology and Bioengineering, 87(5):669-674, 2004. (PDF)


Saifuddin U*,Vu TQ*, Rezac M, Qian H, Pepperberg DR, Desai TA. Toward Development of Bioactive, Neurotransmitter-immobilized Surfaces for Interaction with Post-synaptic Membrane Receptors. Journal of Biomedical Materials Research, 66A(1):184-191, 2003. (*co-authors) . (PDF)


Vu TQ, Payne JA, Copenhagen DC. Localization and developmental expression patterns of the neuronal K-Cl cotransporter (KCC2) in the rat retina. Journal of Neuroscience 20(4):1414-23, 2000. (PDF)


Krizaj D, Vu TQ, and Copenhagen, DC. On the shaping, modulation, and synaptic transmission of rod and cone light responses. In The Retinal Basis of Vision, Toyoda, J., Murakami, M., Kaneko, A., and Saito, T., Eds. Amsterdam: Elsevier, 1999.


Vu TQ, McCarthy ST, and Owen WG. Linear transduction of natural stimuli by dark-adapted and light-adapted rods of the tiger salamander, Tigris Ambystoma. Journal of Physiology 505 (1): 193-204, 1997. (PDF)


(Wai Yan Lam, Yi Wang, Barmak Mostofian, Danielle Jorgens, Sunjong Kwon, KoeiChin, M. Alexandra Carpenter, Thomas Jacob, Katie Heiser, Anurag Agrawal, JingWang, Xiaolin Nan, Young Hwan Chang, Daniel M. Zuckerman, Joe Gray, Marcel Bruchez, Keith A. Lidke, Tania Q. Vu. HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics. bioRxiv --, 2019.


Vermehren-Schmaedick A., Jacob T., Vu TQ. (2018) Methodology for detecting and tracking brain-derived neurotrophic factor complexes in neurons using single quantum dots. Neuromethods. 2018-11

Jacob, T, Malla, P, Vu TQ. (2020) Miniaturized single cell imaging for developing immuno-oncology combinational therapies Methods in Pharmacology and Toxicology. Immuno-Oncology: Cellular and Translational Approaches. Pg 157-165. Humana Press. ISSN1557-2153